Capillary electrochromatography in the pharmaceutical industry. Practical reality or fantasy?

Abstract

Rapid and highly efficient separations of pharmaceutical compounds can be achieved by capillary electrochromatography (CEC) in analyses which are quantitative, reproducible and robust. Columns prepared by packing with a supercritical fluid were highly efficient and gave repeatable, quantitative and sensitive separations. Pressurization of the system and control of column temperature were necessary to prevent bubble formation. The concept of isoeluotropic strength was shown to apply in CEC. Applications to pharmaceutical compounds are described.