Physiological Doses of Secretin Do Not Stimulate Acute Insulin Release*

Abstract

To study the effect of physiological increments in plasma secretin concentrations on basal and glucose-stimulated insulin release, bolus iv glucose injections (5 g) were given to normal weight volunteers (to concentrations seen in the postprandial state fail to alter acute insulin secretion. It is unlikely that secretin plays any role in the intestinal stimulation of insulin secretion.