Salicylate: effects on ion transport and afterpotentials in frog sciatic nerve

Abstract

Ten-millimolar sodium salicylate inhibits almost completely the active transport of Na and K in frog nerve. Salicylate slows and reduces, but does not prevent, the postanoxic hyperpolarization of the nerve fibers, and has little effect on posttetanic hyperpolarization. Although intracellular sodium is required to produce the postanoxic hyperpolarization, these results suggest that active transport of Na or K is not the basis of this requirement.