Prostaglandin modulation of phorbol ester skin tumor promotion

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Abstract
TPA [12-O-tetradecanoylphorbol-13-acetate] promotion of skin tumors in mice can be modified by application of various prostaglandins or their precursors. The effects depend on the particular prostaglandin [PG] used: PGF2.alpha. enhances promotion, whereas PGE1 consistently inhibits promotion. Time of application of the prostaglandin with respect to TPA determines whether PGE2 enhances or inhibits. Dose-dependent inhibition was observed for arachidonic acid. The prostaglandins alone were unable to elicit tumors in initiated mice.