Collagen mimetics
- 7 December 1998
- journal article
- review article
- Published by Wiley in Biopolymers
- Vol. 47 (2), 127-142
- https://doi.org/10.1002/(sici)1097-0282(1998)47:2<127::aid-bip2>3.0.co;2-w
Abstract
Collagen peptidomimetics have been synthesized as an alternative to natural collagen. The incorporation of unnatural residues such as peptoids in the collagen sequences can demonstrate potent and specific biological activity and enhance the biostability against enzymatic degradation. Furthermore, the use of achiral peptoids simplifies synthetic strategies by reducing racemization problems. The peptoid residue N‐isobutylglycine (Nleu) has been successfully incorporated into a series of collagen mimetics composed of Gly‐Pro‐Nleu, Gly‐Nleu‐Pro, and Gly‐Nleu‐Nleu. The discovery of template‐assembled collagen mimetics and metal binding ability has laid the foundation for new opportunities in the design of novel collagen mimetic complexes. This review summarizes the synthesis and integrated biophysical analyses of the structures of these collagen mimetics. Solid phase segment condensation techniques have been utilized for the synthesis of the single chain and template‐assembled analogues. The characterization of the collagen‐like structures has been established by temperature‐dependent optical rotation measurements, CD, NMR spectroscopy, and molecular modelling simulations. © 1998 John Wiley & Sons, Inc. Biopoly 47: 127–142, 1998Keywords
This publication has 67 references indexed in Scilit:
- Attachment of cells to basement membrane collagen type IV.The Journal of cell biology, 1986
- Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagenCell, 1986
- Substrate adhesion of rat hepatocytes: Mechanism of attachment to collagen substratesCell, 1981
- Intracellular Steps in the Biosynthesis of CollagenPublished by Springer Nature ,1976
- Molecular StructurePublished by Springer Nature ,1976
- Primary StructurePublished by Springer Nature ,1976
- Information contained in the amino acid sequence of theα1(I)-chain of collagen and its consequences upon the formation of the triple helix, of fibrils and crosslinksMolecular and Cellular Biochemistry, 1975
- Single crystals of (Pro-Pro-Gly)10, a synthetic polypeptide model of collagenJournal of Molecular Biology, 1972
- The molecular structure of collagenJournal of Molecular Biology, 1961
- Structure of CollagenNature, 1955