A STUDY OF THE EFFECT OF AN ANION EXCHANGE RESIN ON GASTRIC AND DUODENAL SECRETIONS AND GASTRIC EMPTYING 1

Abstract

The anion exchange resin employed in this study is effective in neutralizing acid and inactivating pepsin in the gastric juice of both ulcer and non-ulcer subjects following insulin and repeated dose histamine stimulation. This effect of the resin is comparable to that of a modified Sippy powder and aluminum hydroxide if a sufficiently large dose is employed. The resin caused a substantial reduction in the free acid and pepsin levels and a rise in the pH value in duodenal contents in both ulcer and non-ulcer subjects following repeated histamine stimulation. No untoward effects resulted from the dose of resin used, gastric emptying time was unaffected and rebound in gastric acidity did not occur.