The striatum and cerebral cortex express different muscarinic receptor mRNAs
- 28 March 1988
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 230 (1-2), 90-94
- https://doi.org/10.1016/0014-5793(88)80648-3
Abstract
The existence of four distinct muscarinic acetylcholine receptor genes (m1 – m4) has recently been demonstrated. cDNAs for three of these receptors have been cloned from brain (m1, m3, m4) and one from heart (m2). To gain some understanding of the physiological role of the brain muscarinic receptors, we mapped the distribution of their mRNAs in rat brain by in situ hybridization. These mRNAs are barely detectable in the hindbrain and cerebellum. Within forebrain, each mRNA has a strikingly different pattern of distribution. The highest levels of m1 mRNA are in the cerebral cortex and hippocampus followed by the striatum. m3 mRNA is also prominent in the cerebral cortex, but has very low levels in the striatum. Conversely, the levels of m4 mRNA are highest in the striatum. Since the cognitive effects of muscarinic drugs have been localized to the cerebral cortex and hippocampus, and their psychomotor effects to the striatum, these data suggest that the muscarinic receptors which subserve these responses may be different gene products. Finally, we show that these muscarinic receptors can be distinguished pharmacologically, suggesting that it may be possible to develop drugs for the selective treatment of the psychomotor vs cognitive difficulties of Parkinson's and Alzheimer's disease, respectively.Keywords
This publication has 19 references indexed in Scilit:
- Localization of mRNAs encoding the α‐subunits of signal‐transducing G‐proteins within rat brain and among peripheral tissuesFEBS Letters, 1987
- Identification of a Family of Muscarinic Acetylcholine Receptor GenesScience, 1987
- Molecular distinction between muscarinic acetylcholine receptor subtypesNature, 1987
- Primary Structure and Biochemical Properties of an M 2 Muscarinic ReceptorScience, 1987
- Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequenceFEBS Letters, 1986
- Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptorNature, 1986
- The Cholinergic Hypothesis of Geriatric Memory DysfunctionScience, 1982
- Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal ForebrainScience, 1982
- Physostigmine and Recent Memory: Effects in Young and Aged Nonhuman PrimatesScience, 1979
- SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASEThe Lancet, 1976