Tallysomycin, a new antitumor antibiotic complex related to bleomycin. II. Structure determination of tallysomycins A and B.

Abstract

The structures of tallysomycins A and B, 2 major components of a new antitumor antibiotic complex, were determined. They are glycopeptide antibiotics structurally related to bleomycin: 4 amino acid moieties and a disaccharide fragment which are the constituents of the bleomycin molecule are also present in tallysomycins. Tallysomycins A and B contain 2 new amino acids and a unique amino sugar, 4-amino-4,6-dideoxy-L-talose, which were not hitherto found in the phleomycin-bleomycin group of antibiotics. Tallysomycin A has an additional amino acid, L-.beta.-lysine, and a longer peptide chain than bleomycin or tallysomycin B. Tallysomycins A and B have the same terminal amine moiety, spermidine.