Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication)
- 1 June 1973
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 134 (2), 651-653
- https://doi.org/10.1042/bj1340651
Abstract
The activity of pyruvate dehydrogenase was assayed in extracts of rat hearts perfused in vitro with media containing glucose and insulin±acetate±dichloroacetate. Dichloroacetate (100μm, 1mm or 10mm) increased the activity of pyruvate dehydrogenase in perfusions with glucose or glucose+acetate. Evidence is given that dichloroacetate may facilitate the conversion of pyruvate dehydrogenase from an inactive (phosphorylated) form into an active (dephosphorylated) form.Keywords
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