Highly Enantioselective Synthesis of Propargylic Alcohols by Way of the Asymmetric Aldol Reaction
- 1 June 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 20 (6), 989-992
- https://doi.org/10.1246/cl.1991.989
Abstract
In the presence of a catalytic amount of chiral diamine-coordinated tin(II) triflate, acetylenic aldehydes enantioselectively react with silyl enol ethers of thioesters to afford the corresponding aldol-type adducts, propargylic alcohols, in high yields. The products are easily converted to the corresponding optically active allene derivatives via effective chiral transfer.Keywords
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