The Regulation of Natural Anticoagulant Pathways
- 13 March 1987
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 235 (4794), 1348-1352
- https://doi.org/10.1126/science.3029867
Abstract
Vascular endothelium plays an active role in preventing blood clot formation in vivo. One mechanism by which prevention is achieved involves a cell surface thrombin-binding protein, thrombomodulin, which converts thrombin into a protein C activator. Activated protein C then functions as an anticoagulant by inactivating two regulatory proteins of the coagulation system, factors Va and VIIIa. The physiological relevance of the protein C anticoagulant pathway is demonstrated by the identification of homozygous protein C--deficient infants with severe thrombotic complications. Recent studies suggest that this pathway provides a link between inflammation and coagulation.Keywords
This publication has 58 references indexed in Scilit:
- Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.JCI Insight, 1987
- The Regulation of Hemostasis: The Protein C SystemNew England Journal of Medicine, 1986
- Modulation of endothelial cell hemostatic properties by tumor necrosis factor.The Journal of Experimental Medicine, 1986
- Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor SystemAnnual Review of Cell Biology, 1985
- Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor SystemAnnual Review of Cell and Developmental Biology, 1985
- Natural anticoagulant mechanisms.JCI Insight, 1984
- Homozygous Protein C Deficiency Manifested by Massive Venous Thrombosis in the NewbornNew England Journal of Medicine, 1984
- Congenital Protein C Deficiency and Venous ThromboembolismNew England Journal of Medicine, 1983
- Cultured human endothelial cells generate tissue factor in response to endotoxin.JCI Insight, 1983
- Deficiency of protein C in congenital thrombotic disease.JCI Insight, 1981