TRANSMISSION AT NERVE ENDINGS BY ACETYLCHOLINE

Abstract

Nerve impulses were transmitted by acetylcholine at the endings of motor nerves to skeletal muscle and preganglionic sympathetic fibers, where the duration of its action was brief; and at nerve endings capable of being stimulated by muscarine (embracing postganglionic fibers of the bulbo-sacral parasympathetic outflow plus a certain minority of the thoracico-lumbar outflow), where its action was relatively long. Treating the 2 nerve groups separately, the author reviewed the evidence for this statement and the characteristics of acetylcholine transmission. He also discussed briefly its identification, distr. in body tissues, storage, and possible mode of synthesis.