Does Adrenocortical Hyperplasia Result in Adrenocortical Carcinoma?

Abstract

ONLY 72 cases of masculinizing tumors of the adrenal cortex were reported in a recent twenty-year survey.¹ In the case reported below, symptoms of masculinization were present for thirty years before the removal of an adrenocortical carcinoma. There was responsiveness both to stimulation by ACTH and to inhibition by adrenal corticoids. Both the duration of illness and behavior are exceedingly unusual for such a lesion, although they are not without precedent.Case ReportA 39-year-old colored woman was transferred to Ohio State University Hospital from another hospital on January 18, 1957, for evaluation of the possibility of an adrenal tumor . . .