Micromanagement: A Role for MicroRNAs in mRNA Stability

1 April 2006

journal article
Published by American Chemical Society (ACS) in ACS Chemical Biology

Vol. 1 (3), 132-134
https://doi.org/10.1021/cb600138j

Abstract

Small, inhibitory RNA molecules called microRNAs cause large decreases in target protein levels through a post-transcriptional mechanism. Until recently, it was believed this mechanism operated almost exclusively at a step in translation. However, new work has revealed that microRNAs have a second, post-transcriptional mechanism that accelerates the rate of deadenylation, the initial step of mRNA decay.

Keywords

This publication has 22 references indexed in Scilit:

Short RNAs Repress Translation after Initiation in Mammalian Cells
Molecular Cell, 2006
MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function
Proceedings of the National Academy of Sciences, 2005
Combinatorial microRNA target predictions
Nature Genetics, 2005
miRNP:mRNA association in polyribosomes in a human neuronal cell line
RNA, 2004
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
Cell, 2004
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
Proceedings of the National Academy of Sciences, 2003
Prediction of Mammalian MicroRNA Targets
Cell, 2003
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
Nature, 2000
The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation
Developmental Biology, 1999
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
Cell, 1993

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