Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors
- 30 November 2004
- journal article
- Published by Elsevier in Il Farmaco
- Vol. 59 (11), 887-892
- https://doi.org/10.1016/j.farmac.2004.08.002
Abstract
No abstract availableKeywords
This publication has 17 references indexed in Scilit:
- Targeting RAS signalling pathways in cancer therapyNature Reviews Cancer, 2003
- The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferasesBioorganic & Medicinal Chemistry Letters, 2002
- Coupling of Isoprenoid Triflates with Organoboron Nucleophiles: Synthesis and Biological Evaluation of Geranylgeranyl Diphosphate AnaloguesBioorganic & Medicinal Chemistry, 2001
- Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferaseBioorganic & Medicinal Chemistry Letters, 2001
- Synthesis and evaluation of GGPP geometric isomers: divergent substrate specificities of FTase and GGTase IBioorganic & Medicinal Chemistry Letters, 2001
- Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-IBioorganic & Medicinal Chemistry Letters, 2001
- Ras Protein Farnesyltransferase: A Strategic Target for Anticancer Therapeutic DevelopmentJournal of Clinical Oncology, 1999
- K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase InhibitorsJournal of Biological Chemistry, 1997
- PROTEIN PRENYLATION: Molecular Mechanisms and Functional ConsequencesAnnual Review of Biochemistry, 1996
- Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic miceNature Medicine, 1995