Levels of DDT-Dehydrochlorinase during Metamorphosis of the Resistant House Fly1

Abstract
The detoxication enzyme, DDT-dehydrochlorinase, quantitatively increases during the larval period of the DDT-resistant house fly. A marked reduction in the amount of enzyme, occurring at the time of pupation, may decrease the total activity up to 50%. The resultant level is maintained throughout pupal and adult life. Protein free diets or those supplemented with milk do not significantly affect this level in the adult. Assays on fractions of resistant populations selected at the time of pupation or adult emergence indicate that individuals transforming earlier at these stages contain less DDT-dehydrochlorinase than those pupating or emerging later.