Antidiarrhoeic Activity ofEuphorbia hirtaExtract and Isolation of an Active Flavonoid Constituent

Abstract

The antidiarrhoeic activity of the Euphorbia hirta whole plant was investigated. The lyo-philized decoction demonstrated antidiarrhoeic activity in experimental models of diarrhoea induced by castor oil, arachidonic acid, and prostaglandin E₂. It showed no activity when magnesium sulphate was used to provoke the diarrhoea. The lyophilized decoction delayed small intestinal transit when this was accelerated by castor oil but not in normal conditions. A flavonoid, quercitrin, with antidiarrhoeic activity was isolated from this crude drug.