The preferred conformation of noradrenaline and a consideration of the α-adrenergic receptor
- 1 February 1969
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 21 (2), 93-96
- https://doi.org/10.1111/j.2042-7158.1969.tb08203.x
Abstract
The preferred conformation of noradrenaline has been calculated using extended Hückel molecular orbital theory. The conformation was found to be identical to the previously calculated conformation of (—)-ephedrine in respect to the relation of the quaternary and hydroxyl groups and the phenyl ring. These findings reinforce the previous hypothesis of the nature of the α-adrenergic receptor and also support the view that these molecules function at the receptor in their preferred conformations.Keywords
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