Effect of Isonicotinic Acid Hydrazide on Niacin and Pyridoxine Metabolism in Rats
- 1 February 1955
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 88 (2), 243-246
- https://doi.org/10.3181/00379727-88-21552
Abstract
Isonicotinic acid hydrazide (INH) did not inhibit any of the normal pathways of niacin metabolism investigated in the rat. When added to a B6-deficient ration, INH had a pronounced toxic effect characterized by inhibition of growth, decreased survival time and epileptiform convulsions. The elevated excretion of xanthurenic acid, considered characteristic of the B6-deficient rat, was not apparent in INH-treated animals.Keywords
This publication has 8 references indexed in Scilit:
- EFFECT OF ISONICOTINIC ACID HYDRAZIDE ON DIPHOSPHOPYRIDINE NUCLEOTIDASESJournal of Biological Chemistry, 1954
- THE ISOLATION AND PROPERTIES OF THE ISONICOTINIC ACID HYDRAZIDE ANALOGUE OF DIPHOSPHOPYRIDINE NUCLEOTIDEJournal of Biological Chemistry, 1954
- Effect of Isoniazid on Vitamin B6 Metabolism; Its Possible Significance in Producing Isoniazid Neuritis.Experimental Biology and Medicine, 1954
- Antagonist Studies: Comparison of Desoxypyridoxine and Pyridoxine-Deficiency Therapy on Various Vitamin B6 Enzymes.Experimental Biology and Medicine, 1953
- Relationship of Pyridoxine and its Derivatives to the Mechanism of Action of Isoniazid.Experimental Biology and Medicine, 1953
- ANTAGONISM OF ISONIAZID BY CERTAIN METABOLITESPublished by Elsevier ,1953
- A Rapid Assay for Xanthurenic Acid in UrineExperimental Biology and Medicine, 1951
- A New Salt Mixture for Use in Experimental DietsJournal of Nutrition, 1937