Isolation and characterization of cholecystokinin‐58 (CCK‐58) from porcine brain
- 3 September 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 174 (2), 289-293
- https://doi.org/10.1016/0014-5793(84)81175-8
Abstract
A 58-residue peptide has been isolated from extracts of porcine brain and shown to be an N-terminally extended cholecystokinin (CCK). The amino acid sequence of this peptide is: Ala-Val-Gln-Lys-Val-Asp- Gly-Glu-Ser-Arg-Ala-His-Leu-Gly-Ala-Leu-Leu-Ala-Arg-Tyr-Ile-Gln-Gln-Ala-Arg-Lys-Ala-Pro-Ser-Gly- Arg-Val-Ser-Met-Ile-Lys-Asn-Leu-Gln-Ser-Leu-Asp-Pro-Ser-His-Arg-Ile-Ser-Asp-Arg-Asp-Tyr(SO3)-Met- Gly-Trp-Met-Asp-Phe-NH2. The peptide was found to induce contraction of the guinea-pig gallbladder, but the pattern of this action seemed to differ from those of CCK-8 and CCK-33.Brain peptideGut peptideBrain CCKCCK-58Amino acid sequenceC-terminal amidKeywords
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