Detection of Human Immunodeficiency Virus Type 1 Provirus in Mononuclear Cells by in Situ Polymerase Chain Reaction
- 21 May 1992
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 326 (21), 1385-1391
- https://doi.org/10.1056/nejm199205213262103
Abstract
Studies of human immunodeficiency virus type 1 (HIV-1) infection have attempted to quantitate the viral load and correlate it with the degree of immune deficiency. In one study, only about 1 in 10,000 peripheral-blood mononuclear cells (PBMC) expressed HIV-1, but in other studies, at least 1 in 100 CD4-positive cells was infected and harbored the HIV-1 provirus.Keywords
This publication has 42 references indexed in Scilit:
- Transient High Levels of Viremia in Patients with Primary Human Immunodeficiency Virus Type 1 InfectionNew England Journal of Medicine, 1991
- High Titers of Cytopathic Virus in Plasma of Patients with Symptomatic Primary HIV-1 InfectionNew England Journal of Medicine, 1991
- Specific Tropism of HIV-1 for Microglial Cells in Primary Human Brain CulturesScience, 1990
- HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structureCell, 1990
- Quantitation of Human Immunodeficiency Virus Type 1 in the Blood of Infected PersonsNew England Journal of Medicine, 1989
- Infection of the Retina by Human Immunodeficiency Virus Type INew England Journal of Medicine, 1987
- Survival with the Acquired Immunodeficiency SyndromeNew England Journal of Medicine, 1987
- Perinatal Infection with Human Immunodeficiency VirusNew England Journal of Medicine, 1987
- Pathogenesis of Infection with Human Immunodeficiency VirusNew England Journal of Medicine, 1987
- Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Science, 1983