Acute Neurologic Reaction to Promethazine

Abstract

A BRIEF glance at the medical literature over the past few years gives sufficient assurance of the relatively frequent and unusual clinical pattern of phenothiazine toxicity.^{1 2 3 4} This report is not intended as a review of the literature on this subject.As would most likely be expected, even drugs of this group considered least toxic will from time to time cause difficulty of a severe degree. The following report demonstrates such an episode initiated by a small single dose of promethazine.Case ReportA 5-year-old boy became ill 9 days before admission, with symptoms of fever, cough and coryza. The temperature . . .