Comparison of ranitidine and cimetidine in the inhibition of histamine, sham-feeding, and meal-induced gastric secretion in duodenal ulcer patients.
- 1 March 1980
- Vol. 21 (3), 181-186
- https://doi.org/10.1136/gut.21.3.181
Abstract
The effects of ranitidine, a new H2-receptor antagonist which does not contain an imidazole ring, and cimetidine were determined on histamine, meal-induced gastric acid secretion and serum gastrin levels in duodenal ulcer patients. Compared with cimetidine, ranitidine was .apprx. 8 times more potent an inhibitor of histamine-induced secretion and 4-5 times more potent an inhibitor of sham-feeding, and real feeding induced acid secretion without effecting serum gastrin levels.This publication has 25 references indexed in Scilit:
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