Red-Cell Choline in Manic-Depressive Patients Taking Lithium
- 18 September 1980
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 303 (12), 705
- https://doi.org/10.1056/nejm198009183031223
Abstract
To the Editor: The interesting observation of Jope et al. (October 12, 1978 issue) that choline accumulates in the erythrocytes of manic-depressive patients treated with lithium carbonate led us to screen 14 such patients, to assess whether there is any correlation between these choline levels and therapeutic response. Measurement of choline in the erythrocytes was facilitated by a technique that has only recently been applied to the study of small metabolites in whole cells — proton (1H) spin-echo Fourier transform nuclear magnetic resonance.1 2 3 The samples of blood from the patients were withdrawn under standard conditions4 and sent for lithium . . .Keywords
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