Mitomycin C: Chemical and Biological Studies on Alkylation
- 29 November 1963
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 142 (3596), 1181-1183
- https://doi.org/10.1126/science.142.3596.1181
Abstract
The presence of an aziridine ring in mitomycin C suggests that the mechanism of action of the antibiotic is like that of the antitumor alkylating agents. However the compound is unexpectedly stable during aerobic incubation with rat liver homogenates although rapidly metabolized anaerobically. Mitomycin is not reactive with γ-(4-nitrobenzyl) pyridine and reacts only slowly at acid pH with thiosulfate. It is proposed that mitomycin is activated in vivo, possibly by a reduction which "unmasks" the potential activity of the fused aziridine ring.Keywords
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