The Calcineurin Target, Crz1, Functions in Azole Tolerance but Is Not Required for Virulence of Candida albicans
Open Access
- 1 December 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (12), 7330-7333
- https://doi.org/10.1128/iai.72.12.7330-7333.2004
Abstract
In Candida albicans , calcineurin is essential for virulence and survival during membrane perturbation by azoles. Crz1 is a proposed downstream target of calcineurin based on studies of Saccharomyces cerevisiae . However, the in vitro phenotypes of C. albicans crz1/crz1 and calcineurin mutants differ and Crz1 is not required for virulence.Keywords
This publication has 19 references indexed in Scilit:
- Regulation of azole drug susceptibility by Candida albicans protein kinase CK2Molecular Microbiology, 2005
- Hph1p and Hph2p, Novel Components of Calcineurin-Mediated Stress Responses in Saccharomyces cerevisiaeEukaryotic Cell, 2004
- Calcineurin Is Essential for Virulence in Candida albicansInfection and Immunity, 2003
- Calcineurin Is Essential for Candida albicans Survival in Serum and VirulenceEukaryotic Cell, 2003
- Ergosterol Biosynthesis Inhibitors Become Fungicidal when Combined with Calcineurin Inhibitors against Candida albicans , Candida glabrata , and Candida kruseiAntimicrobial Agents and Chemotherapy, 2003
- Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking siteGenes & Development, 2002
- Calcineurin is essential for survival during membrane stress in Candida albicansThe EMBO Journal, 2002
- Candida albicans RIM101 pH Response Pathway Is Required for Host-Pathogen InteractionsInfection and Immunity, 2000
- Nosocomial Candidemia: Risk Factors and Attributable MortalityClinical Infectious Diseases, 1995
- Secular Trends in the Epidemiology of Nosocomial Fungal Infections in the United States, 1980-1990The Journal of Infectious Diseases, 1993