Massive renal infarction with perirenal hematoma formation occurring in sickle-cell trait has not been previously reported. Various renal complications in patients with sickle-cell trait have been described by Harrow (5), Kay (6), and Vix (13), but no cases of extensive renal infarction were included. The present report describes infarction of the kidney and demonstrates the radiographic features of perirenal hematoma in the sickle-cell trait. The association of sickle-cell hemoglobinopathy and hematuria was first reported by Goodwin in 1950. Since then hematuria and renal papillary necrosis have been described in hemoglobin SA, SC, and SD disease (5, 6, 13). Gunnells and Grim (4), reporting hematuria in AD hemoglobinopathy, emphasized that hemoglobinopathies must be considered in cases of “essential” or “unexplained” hematuria. Case Report A 33-year-old Negro laborer was hospitalized with right upper quadrant abdominal pain of twelve hours duration. During the preceding two years the patient had experien...