Induction of Lung Cancers in Preselected, Localized Sites in the Dog23
Open Access
- 1 November 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 65 (5), 921-927
- https://doi.org/10.1093/jnci/65.5.921
Abstract
Cancers were induced in 10 dogs in preselected sites within the lung. These 10 animals were among 89 dogs enrolled in 10 protocols with different carcinogens, doses, and techniques over 6 years. The 10 dogs that developed cancers were included in five of these protocols; 4 of the cancers were included in one of the protocols. The administered carcinogens included the aromatic hydrocarbons benzo[a]pyre ne (BP), N-methyl-N-nitrosourea (MNU), 7,12-dimethylbenz[a]anthracene (DMBA), 3-methylcholanthrene (MCA), and yttrium-91 (91Y) beta radiation. The techniques of application included intrabronchial and intrapulmonary sustained-release implants of DMBA and91Y, serial intrabronchial submucosal injections of BP, DMBA, and MCA, or topical application of MNU. The intervals from the first application of a carcinogen to the diagnosis of malignant disease ranged from 8 to 56 months. Of the tumors induced, 9 were centrally located squamous cell carcinomas and 1 was a peripherally located carcinosarcoma. Four of the dogs were killed or died with stage 3 disease. The remaining 6 dogs are alive and are being evaluated serially; all 6 are in stage 1.Keywords
This publication has 5 references indexed in Scilit:
- Cytologic Correlates of Chemical Carcinogens in Respiratory Tracts of Dogs2JNCI Journal of the National Cancer Institute, 1978
- Morphologic aspects of experimental canine bronchial carcinogen exposureEuropean Journal of Cancer (1965), 1978
- Effects of localized chemical carcinogenesis and immunosuppression upon bronchial preneoplasia in the dogThe Journal of Thoracic and Cardiovascular Surgery, 1977
- EXPERIMENTAL CANINE TRACHEAL GRAFTS WITH REVERSIBLE SQUAMOUS METAPLASIAPublished by Elsevier ,1977
- The effect of cigarette smoke condensate on the bronchial mucosa of dogsCancer, 1962