Labeled aryl fluorides from the nucleophilic displacement of activated nitro groups by 18F‐F−

Abstract

Nucleophilic displacement of activated nitro groups by ¹⁸F‐fluoride ion is an efficient route to fluorine‐18 labeled aromatics, which can be obtained in the no‐carrier‐added state if required.The basic features of the fluorodenitration process are comparatively evaluated, and the influence of the experimental variables on its course are discussed. Examples concerning the preparation of typical ¹⁸F‐labeled aromatic molecules are reported.