Spinal 5-HT or NA Uptake Inhibition Potentiates Supraspinal Morphine Antinociception in Rats
- 1 January 1984
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 54 (1), 72-75
- https://doi.org/10.1111/j.1600-0773.1984.tb01897.x
Abstract
Spinal injection of the specific uptake inhibitor of 5-hydroxytryptamine (5-HT), citalopram, or of noradrenaline (NA), desipramine, potentiated the antinociception following intracerebroventricular injection of morphine in rats tested on the hot plate. Combined spinal injection of citalopram and desipramine caused a synergistic potentiation. The unselective and less potent inhibitor of both 5-HT and NA uptake, amitriptyline, did not cause potentiation. The results support the suggested involvement of both 5-HT and NA pathways in supraspinal morphine antinociception.Keywords
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