Recognition and Stabilization of Peptide α-Helices Using Templatable Nanoparticle Receptors
- 14 August 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (35), 10806-10807
- https://doi.org/10.1021/ja047719h
Abstract
α-Helices are important structural elements in proteins. To provide a scaffold for the facial recognition of peptides, we have explored the interaction of cationic mixed monolayer protected clusters (MMPCs) with a tetra-aspartate peptide in water. In these studies, substantial enhancement of peptide helicity was observed upon addition of the MMPC. Significantly, this stabilization increased with time, demonstrating templation of the monolayer to the peptide helix.Keywords
This publication has 12 references indexed in Scilit:
- Helical templating of oligopeptides by cyclodextrin dimersBioorganic & Medicinal Chemistry, 2003
- DICHROWEB: an interactive website for the analysis of protein secondary structure from circular dichroism spectraBioinformatics, 2002
- Zn(II) dipicolylamine-based artificial receptor as a new entry for surface recognition of α-helical peptides in aqueous solutionTetrahedron Letters, 2001
- Surface Recognition and Helix Stabilization of a Tetraaspartate Peptide by Shape and Electrostatic Complementarity of an Artificial ReceptorJournal of the American Chemical Society, 1999
- Surface-Confined Nanoparticles as Substrates for Photopolymerizable Self-Assembled MonolayersAdvanced Materials, 1999
- Estimation of the number of α‐helical and β‐strand segments in proteins using circular dichroism spectroscopyProtein Science, 1999
- Some new developments and challenges in non-covalent molecular imprinting technologyJournal of Molecular Recognition, 1998
- Recognition and Stabilization of an α-Helical Peptide by a Synthetic ReceptorJournal of the American Chemical Society, 1997
- Macrocycles containing tin. The preparation of macrobicyclic Lewis acidic hosts containing two tin atoms and tin-119 NMR studies of their chloride and bromide binding properties in solutionThe Journal of Organic Chemistry, 1989
- Derivative spectroscopy applied to tyrosyl chromophores. Ribonuclease, lima bean inhibitors, insulin, and pancreatic trypsin inhibitorBiochemistry, 1973