Extended in vivo blood circulation time of fluorinated liposomes
- 28 December 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 336 (3), 481-484
- https://doi.org/10.1016/0014-5793(93)80860-w
Abstract
The clearance from blood circulation of fluorinated liposomes made with perfluoroalkylated phosphatidylcholines was investigated in mice using liposome-entrapped 5(6)-carboxyfluorescein. The presence of a fluorinated core inside the membrane strongly retards their blood clearance. The fluorinated vesicles showed circulation half-lives of up to 8.6 h, which are 6–13 and 3–6 times larger than those of similarly sized conventional distearoylphosphatidylcholine and distearoylphosphatidylcholine/cholesterol liposomes, respectively. Their blood clearance was similar to that of some polyethylene glycol (PEG)-labelled ‘stealth’ liposomes and was dose-independent in a 3.3–330 body weight dose range.
Keywords
This publication has 14 references indexed in Scilit:
- Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.Proceedings of the National Academy of Sciences, 1991
- Pharmacokinetics of stealth versus conventional liposomes: effect of doseBiochimica et Biophysica Acta (BBA) - Biomembranes, 1991
- Highly Stable Liposomes Derived from Perfluoroalkylated GlycerophosphocholinesAngewandte Chemie International Edition in English, 1991
- Liposomes for the sustained drug release in vivoBiochimica et Biophysica Acta (BBA) - Biomembranes, 1990
- Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomesFEBS Letters, 1990
- Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.Proceedings of the National Academy of Sciences, 1988
- Large unilamellar liposomes with low uptake into the reticuloendothelial systemFEBS Letters, 1987
- Tissue distribution of liposomes exhibiting long half-lives in the circulation after intravenous injectionBiochimica et Biophysica Acta (BBA) - General Subjects, 1985
- Colorimetric determination of phospholipids with ammonium ferrothiocyanateAnalytical Biochemistry, 1980
- Stability of liposomes invivo and invitro is promoted by their cholesterol content and the presence of blood cellsBiochemical and Biophysical Research Communications, 1979