Gastric Contractions in the Rat

Abstract

A method is described for continuous recording of gastric concentrations in the normal rat. Fasting concentrations normally show a cyclical behavior with a period of 15–20 minutes. These concentrations are inhibited by instillation of many substances into the stomach via a permanent gastric fistula, the duration of the inhibition varying with volume and concentration. Neither glucose nor insulin given i.v. affects the fasting contractions; however, 0.1 mg of intravenous glucagon invariably produces complete inhibition of contractions for 4–7 minutes.