Renal function in streptozotocin-diabetic rats
- 1 October 1981
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 21 (4), 409-414
- https://doi.org/10.1007/bf00252690
Abstract
Renal function was examined with micropuncture methods in the insulin-treated streptozotocin-diabetic rat. Kidney glomerular filtration rate was significantly higher in the diabetic rats (1.21 ml/min) than in the control group (0.84 ml/min) Nephron glomerular filtration rate increased in proportion to the rise in kidney glomerular filtration rate (diabetic rats: 37.0 nl/min; control rats: 27.9 nl/min). Likewise renal plasma flow was significantly higher in the diabetic rats (4.1 ml/min) than in the control group (3.0 ml/min). Glomerular capillary pressure was identical in both groups (56.0 and 56.0 mmHg, respectively). The proximal intratubular pressure was significantly reduced in the diabetic rats (10.4 mmHg; control value: 12.5 mmHg). The effective glomerular ultrafiltration coefficient was slightly but not significantly higher in the diabetic rats (0.027 nl s-1mmHg-1) than in the control group (0.023 nl s-1mmHg-1). Kidney weight was significantly higher in the diabetic rats (1.15 g; control rats: 0.96 g) while body weight was similar in both groups (diabetic rats: 232 g; control rats: 238 g). Calculations indicate that the increases in transglomerular hydraulic pressure, renal plasma flow and ultrafiltration co-efficient of the glomerular membrane contribute about equally to the rise in glomerular filtration rate. The increases in the values of the determinants of glomerular filtration rate may be the result of renal hypertrophy. These studies suggest that this model provides a useful method for investigating kidney function in diabetes, which may have relevance for our understanding of the kidney abnormalities in human diabetes.Keywords
This publication has 30 references indexed in Scilit:
- Morphometry of the renal corpuscle during postnatal growth and compensatory hypertrophyKidney International, 1980
- Glomerular capillary pressure in the ratActa Physiologica Scandinavica, 1979
- Control of blood glucose levels in the streptozotocin diabetic rat using a long-acting heat-treated insulinDiabetologia, 1979
- Mechanics of Glomerular UltrafiltrationNew England Journal of Medicine, 1977
- Single-nephron pressures, flows, and resistances in hypertensive kidneys with nephrosclerosisKidney International, 1977
- Glomerular size and structure in diabetes mellitusDiabetologia, 1977
- Relation of distal tubular NaCl delivery and glomerular hydrostatic pressureKidney International, 1972
- Abnormal Glomerular Filtration Rate, Renal Plasma Flow, and Renal Protein Excretion in Recent and Short-term DiabeticsBMJ, 1972
- Glomerular Filtration Rate and Renal Plasma Flow in Short-term and Long-term Juvenile Diabetes MellitusScandinavian Journal of Clinical and Laboratory Investigation, 1971
- Functional correlates of compensatory renal hypertrophyJCI Insight, 1968