Ca2+ and phorbol ester synergistically induce HL‐60 differentiation
- 29 September 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 206 (1), 99-105
- https://doi.org/10.1016/0014-5793(86)81348-5
Abstract
Exposure of HL-60 cells to subthreshold concentrations of TPA caused monocytic differentiation only when cells were cotreated with the Ca2+ ionophore A23187. Phorbol ester dose-response curves for growth arrest and enzymatic markers of differentiation were shifted to lower concentrations when the ionophore was present. Expression of a monocyte/granulocyte cell surface antigen also occurred only when cells were treated with both agents. Similar effects were seen with other active but not inactive phorbol esters and with another Ca2+ ionophore. The Ca2+ component of phosphoinositide-based signalling may thus play a role in HL-60 differentiationKeywords
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