Phosphatidylkojibiosyl diglyceride: Metabolism and function as an anchor in bacterial cell membranes
- 1 July 1975
- Vol. 10 (7), 421-426
- https://doi.org/10.1007/bf02532448
Abstract
The recently discovered phosphoglycolipid, phosphatidylkojibiosyl diglyceride (PKD), was first observed as a biosynthetic by-product of glucosyl diglyceride metabolism inStreptococcus faecalis (faecium) ATCC 9790. Its structure is 1,2-diacyl-3-O(2′-O-α-D-glucopyranosyl-6′-O-phosphoryl-[1″,2″-diacyl-3″-O-sn-glycerol]-α-D-glucopyranosyl)-sn-glycerol. The biosynthesis of phosphatidylkojibiosyl diglyceride occurs by a novel transphosphatidylation reaction in which a phosphatidyl group is transferred from diphosphatidyl glycerol to the primary alcohol function at the 6 position of the internal glucose of kojibiosyl diglyceride. The reaction is catalyzed by a membrane-derived enzyme. Phosphatidylkojibiosyl diglyceride is bound covalently through a phosphodiester bond to the polyglycerol phosphate moiety of membrane lipoteichoic acid fromS. faecalis. Phosphatidylkojibosyl diglyceride has four nonpolar long chain fatty acyl groups and appears to have the necessary physico-chemical properties to anchor the long hydrophilic glycerol phosphate polymer of lipoteichoic acid to the hydrophobic environment of the membrane ofS. faecalis and probably other gram-positive bacteria as well.Keywords
This publication has 29 references indexed in Scilit:
- Cellular location of the lipoteichoic acids of Lactobacillus fermenti NCTC 6991 and Lactobacillus casei NCTC 6375Journal of Ultrastructure Research, 1973
- Phospholipids of a moderately halophilic halotolerant bacterium: Isolation and identification of glucosylphosphatidyl-glycerolBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1973
- Glycerophosphoryl diglucosyl diglyceride, a new phosphoglycolipid from StreptococciBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1973
- Biosynthesis of the phosphatidyl diglucosyl diglyceride of Streptococcus,faecalis (ATCC 9790) from diglucosyl diglyceride and phosphatidyl glycerol or diphosphatidyl glycerolBiochemical and Biophysical Research Communications, 1972
- A new phosphoglycolipid from streptococcus lactisBiochemical and Biophysical Research Communications, 1970
- Studies on the Group F Antigen of Lactobacilli: Isolation of a Teichoic Acid-Lipid Complex from Lactobacillus fermenti NCTC 6991Journal of General Microbiology, 1970
- IMMUNOCHEMICAL ANALYSIS OF MYCOPLASMA PNEUMONIAEImmunology & Cell Biology, 1969
- Structural investigations on glucosaminyl phosphatidylglycerol from Bacillus megateriumBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1969
- Glycolipids containing glucose and uronic acids in Pseudomonas speciesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1968
- Structure and Distribution of Glycosyl Diglycerides in BacteriaNature, 1968