A Renal Factor in Hypertension Due to Coarctation of the Aorta

Abstract

RENAL disease is instrumental in the generation or maintenance of some forms of systemic arterial hypertension. The experimental production of systolic hypertension by renal artery constriction, by suprarenal coarctation of the aorta, or by establishment of fibrocollagenous perinephritis in animals suggests a renal factor in such hypertension involving an alteration of renal blood flow or renal ischemia per se.^{1 2 3 4} The clinical counterpart of this assumption stems from the recorded success of reconstructive procedures reversing hypertension in patients with renal-artery stenosis.^{5 , 6} The correction of hypertension by removal of an ischemic kidney, the physiochemical function of which is measurably altered, further fosters . . .