Rare Earth Metal Ions for DNA Hydrolyses and Their Use to Artificial Nuclease1
- 1 July 1994
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 13 (6-7), 1297-1309
- https://doi.org/10.1080/15257779408012152
Abstract
Phosphodiester linkages in linear DNAs are efficiently hydrolyzed by rare earth metal salts. The activities of CeCl3 and Ce(NH4)2(NO3)6 are especially large. Artificial hydrolytic nuclease for highly selective scission of DNA has been prepared by the attachment of Ce(IV) ion to a DNA oligomer as a sequence recognizing moiety.Keywords
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