Relationship between Ragweed-Reagins and Serum Immunoglobulins
- 1 January 1966
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 30 (6), 542-552
- https://doi.org/10.1159/000229841
Abstract
The sera of 6 ragweed-allergic patients were separately chromatographed on DEAE-Sephadex A-50. The bulk of the reaginic antibodies were localized in DEAE-Sephadex fractions containing [gamma]G and devoid of [gamma] A globulins. The rest of the reaginic antibodies were found In fractions containing both types of immunoglobulin. Fractions containing [gamma] M globulin were inactive. Immuno-absorption of the reaginicaUy active fractions with antisera specifc to [gamma] G and [gamma] A globulins was without effect on the reaginic activity of these fractions. The relationship between reagins and [gamma] D globulin was discussed. Ragweed-reagins belongs to an uncharacterized immunoglobulin class.This publication has 5 references indexed in Scilit:
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- THE SEDIMENTATION PROPERTIES OF THE SKIN-SENSITIZING ANTIBODIES OF RAGWEED-SENSITIVE PATIENTSThe Journal of Experimental Medicine, 1964
- Gel filtration of human skin-sensitizing antibody and β2A-globulinJournal of Allergy, 1964
- Blocking of Prausnitz-Küstner sensitization with reagin by normal human β2A globulinJournal of Allergy, 1963
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