Histochemical Changes in Kidneys and in Salivary Glands of Rats with Experimental Hypertension

Abstract

Summary In rats with experimental hypertension due either to overdosage with DCA and salt or to unilateral clamping of renal artery, activity of glucose-6-phosphate dehydrogenase (G6PD) was determined histochemically in the macula densa and simultaneously in ducts of submaxillary gland. In both kidneys of animals with DCA hypertension and in unclamped kidney of animals with renal hypertension, G6PD is diminished to a comparable degree, both in macula densa cells and in the duct epithelium of submaxillary gland, whereas activity in the clamped kidney is higher than normal. Simultaneously there is a widening of ducts in the salivary gland comparable to that seen in cortical tubular system in the kidney. Adrenalectomy is followed by increased G6PD activity in the macula densa and a high normal activity in the submaxillary gland.