Failure of Vancomycin Treatment in Staphylococcus aureus Endocarditis
- 4 October 1976
- journal article
- research article
- Published by American Medical Association (AMA)
- Vol. 236 (14), 1604-1606
- https://doi.org/10.1001/jama.1976.03270150038029
Abstract
In a case of staphylococcal endocarditis, we failed to eradicateStaphylococcus aureusfrom the blood stream with vancomycin hydrochloride therapy. The strain involved was sensitive to vancomycin by disk diffusion studies but showed a wide disparity between minimal inhibitory and minimal bactericidal concentrations. The lack of a bactericidal effect was probably responsible for the failure of treatment. A synergistic effect was demonstrated for the combination of gentamicin sulfate and methicillin sodium, and the patient was ultimately cured with this combination plus vancomycin. Bactericidal tests are important in choosing an antimicrobial agent for treatment of endocarditis. (JAMA236:1604-1606, 1976)Keywords
This publication has 2 references indexed in Scilit:
- Enhancement of the Effects of Anti-Staphylococcal Antibiotics by AminoglycosidesAntimicrobial Agents and Chemotherapy, 1974
- Vancomycin in Serious Staphylococcal InfectionsArchives of Internal Medicine, 1962