Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry
- 24 March 2009
- journal article
- letter
- Published by American Chemical Society (ACS) in The Journal of Physical Chemistry C
- Vol. 113 (15), 5891-5894
- https://doi.org/10.1021/jp900266k
Abstract
High resolution localized surface plasmon resonance (HR-LSPR) sensors were combined with matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) for the first time. LSPR sensors provide real-time label-free detection of molecular adsorption. Subsequent MALDI-MS analysis enables identification of the adsorbed molecules. This synergistic LSPR-MS approach was applied to the detection and identification of amyloid beta oligomers which play an important role in the molecular pathogenesis of Alzheimer’s Disease.Keywords
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