Effect of Verapamil on pancreatic glucagon release from the isolated, perfused canine pancreas
- 1 January 1977
- journal article
- Published by Taylor & Francis in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 37 (2), 139-142
- https://doi.org/10.3109/00365517709156068
Abstract
The effect of Verapamil, a potent calcium antagonist, upon pancreatic glucagon release was investigated in the isolated, perfused canine pancreas. Verapamil at concentrations ranging between 10−5-10−4 mol/I caused a dosc-related inhibition of glucagon release at a glucose concentration of 25 mg/dl. The inhibition was an immediate and reversible phenomenon. The inhibitory effect was reduced when the Ca2+ concentration was increased from 1.3 to 5.0 mmol/I. The results are compatible with earlier findings from our laboratory demonstrating that calcium plays a key role in the stimulus-secretion coupling of glucagon release.Keywords
This publication has 8 references indexed in Scilit:
- Calcium-antagonists and islet function. IV. effect of D600Diabetologia, 1976
- Calcium Antagonists and Islet Function: I. Inhibition of Insulin Release by VerapamilDiabetes, 1975
- Adrenergic Receptors and the Secretion of Glucagon and Insulin from the Isolated, Perfused Canine PancreasJCI Insight, 1973
- Secretion of glucagon from the isolated, perfused canine pancreasJCI Insight, 1971
- Uterus-Relaxation durch hochaktive Ca++-antagonistische Hemmstoffe der elektro-mechanischen Koppelung wie Isoptin (Verapamil, Iproveratril), Substanz D 600 und Segontin (Prenylamin)Klinische Wochenschrift, 1971
- Wick Chromatography for Rapid and Reliable Immunoassay of Insulin, Glucagon and Growth HormoneNature, 1968
- The role of calcium and magnesium in insulin secretion from rabbit pancreas studied in vitroDiabetologia, 1967
- Cation Requirements for Insulin Secretion in the Isolated Perfused PancreasDiabetes, 1966