THE MECHANISM OF FORMATION OF OSMOTICALLY CONCENTRATED URINE DURING THE ANTIDIURETIC STATE 1
Open Access
- 1 July 1954
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 33 (7), 1064-1074
- https://doi.org/10.1172/jci102974
Abstract
The urinary concentrating process was examined in 54 tests on 31 normal subjects in the antidiuretic state by the induction of osmotic (mannitol) diuresis at urine flows ranging from 5 to 40 ml./min. Antidiuresis was induced either by abstinence from fluids for 12 to 14 hrs. (hydropenia), by hydropenia supplemented by Pitressin, or by the admn. of Pitressin to hydrated subjects. The degree of osmotic concn. of the urine was determined by application of the cryoscopic method to plasma and urine, and the calculation of the quantity of water (in ml./min. and here designated as TCH2O) required to restore the urine to an isosmotic state with respect to the glomerular filtrate. The conclusion is reached that the concentrating mechanism operates essentially by the removal of a constant max. quantity of solute-free water irrespective of the urine flow so long as the latter somewhat exceeds this max. reabsorptive rate. It is believed that unknown factors operate systematically in some individuals or under certain circumstances to cause slight, regular increases or decreases in TcH2O with increasing diuresis. This concentrating operation appears to be generally identical whether the anti-diuretic state is induced by endogenous antidiuretic hormone, by Pitressin in physiological doses, or both.This publication has 10 references indexed in Scilit:
- Site of Saluretic Action of an Organic Mercurial CompoundJournal of Applied Physiology, 1953
- Urinary Concentrating Mechanism in the DogAmerican Journal of Physiology-Legacy Content, 1952
- Renal excretion of sodium and water.1952
- Effect of Osmotic and Mercurial Diuresis on Simultaneous Water DiuresisAmerican Journal of Physiology-Legacy Content, 1952
- III. Electrolyte excretion studies in the dog.1952
- IV. Determination of water and electrolyte excretion during osmotic diuresis in hydropenic man.1952
- Renal Excretion of Sodium and Water in Man as Affected by Prehydration, Saline Infusion, Pitressin and ThiomerinJournal of Applied Physiology, 1952
- THE MECHANISM OF GLYCOSURIC DIURESIS IN DIABETIC MAN 1Journal of Clinical Investigation, 1950
- Significance of the renal juxtamedullary circulation in manAmerican Journal Of Medicine, 1950
- Determination of Inulin by Means of ResorcinolExperimental Biology and Medicine, 1950