Brief Communication: Antitumor Action of Vitamin A in Mice Inoculated With Adenocarcinoma Cells2

Abstract

Vitamin A palmitate was incorporated into a laboratory chow (150,000 IU/kg diet) and fed ad libitum to C3H/HeJ female mice inoculated with 1 × 10⁶ C3HBA tumor cells, beginning the day of inoculation. Control female mice of the same strain similarly inoculated were fed the laboratory chow alone. Vitamin A did not affect tumor incidence, but it did decrease the tumor growth rate for the first 19 days, after which growth rates were independent of treatment. Vitamin A-treated mice survived for significantly longer times than did control mice.