EFFECTS OF COMBINATIONS OF PHENCYCLIDINE AND PENTOBARBITAL ON FIXED-INTERVAL PERFORMANCE IN RHESUS-MONKEYS
- 1 January 1981
- journal article
- research article
- Vol. 217 (3), 611-618
Abstract
The effects of PCP (0.1-0.8 mg/kg), pentobarbital (PB, 2-32 mg/kg) and of combinations of these 2 drugs were determined in rhesus monkeys trained to respond on a fixed-interval 5 min schedule of food presentation. When combinations of PCP and PB were tested, dose-effect functions for PB on overall response rate were shifted to the left relative to those for PB given alone. This effect was dependent on PCP dose: the higher dose of PCP (0.2 mg/kg) shifted the PB dose-effect function further than did the lower dose (0.1 mg/kg). The effects of both drugs alone and in combination depended upon the rate of responding under control conditions. Individual drugs and combinations increased low rates of responding, increased and then at higher doses decreased intermediate rates of responding and only decreased high rates of responding. Nevertheless, the effects of combinations of PCP and PB were always shifted to the left relative to PB given alone. This interaction was quantified by using isobolograms for those dependent measures that were decreased by the 2 drugs given alone or in combination. This analysis revealed that the nature of the interaction between PCP and PB depended upon the dose combination and the measure of performance. Relative to the predictions of a dose-addition model, the interaction was quantitatively greater (additive or supra-additive) when the lower dose of PCP was combined with PB.This publication has 15 references indexed in Scilit:
- The effects of phencyclidine on ethanol and sodium hexobarbital in miceToxicology and Applied Pharmacology, 1977
- Interaction of d-amphetamine with pentobarbital and chlordiazepoxide: Effects on punished and unpunished behavior of pigeonsPharmacology Biochemistry and Behavior, 1976
- EFFECTS OF PHENCYCLIDINE, KETAMINE, D-AMPHETAMINE AND PENTOBARBITAL ON SCHEDULE-CONTROLLED BEHAVIOR IN MOUSE1976
- EFFECTS OF ALCOHOL, CHLORDIAZEPOXIDE, COCAINE AND PENTOBARBITAL ON RESPONDING MAINTAINED UNDER FIXED-INTERVAL SCHEDULES OF FOOD OR SHOCK PRESENTATION1976
- EFFECT OF PHENCYCLIDINE AND KETAMINE ON SCHEDULE-CONTROLLED BEHAVIOR IN PIGEON1976
- DRUG EFFECTS IN SQUIRREL MONKEYS TRAINED ON A MULTIPLE SCHEDULE WITH A PUNISHMENT CONTINGENCYJournal of the Experimental Analysis of Behavior, 1967
- INFLUENCE OF DRUGS ON BEHAVIOR CONTROLLED BY INTERNAL AND EXTERNAL STIMULI1966
- Interactions between the effects of methamphetamine and pentobarbital on operant behavior in the pigeonPsychopharmacology, 1965
- THE RELATIONS' AMONG MEASURES OF PERFORMANCE ON FIXED‐INTERVAL SCHEDULES1Journal of the Experimental Analysis of Behavior, 1964
- MUTUAL POTENTIATION OF AMPHETAMINE AND AMYLOBARBITONE MEASURED BY ACTIVITY IN RATSBritish Journal of Pharmacology and Chemotherapy, 1963