Compensatory carotid artery dilatation in early atherosclerosis.
- 1 June 1994
- journal article
- abstracts
- Published by Wolters Kluwer Health in Circulation
- Vol. 89 (6), 2578-2581
- https://doi.org/10.1161/01.cir.89.6.2578
Abstract
BACKGROUNDFrom pathological studies of coronary arteries, it has been recognized that progressive plaque development may be compensated for by an increase of the arterial diameter. However, the dynamics of this process have not been investigated, and it is not known whether compensatory dilatation is a general pathomechanism in human arteries.METHODS AND RESULTSUsing a high-resolution duplex scanner and subsequent three-dimensional plaque reconstruction, we prospectively studied the effect of carotid plaque development on the vascular geometry in 32 patients at 6- to 12-month intervals. Plaque progression in 41% (n = 26) of studies was associated with an increase of the vessel diameter between 0.4 and 1.2 mm in 76% (n = 20). Among 36 unchanged plaque developments, enlargement of the arterial diameter was assessed in only 28% (n = 10) (P < .001).CONCLUSIONSOur data suggest that increasing plaque volume is significantly associated with enlargement of carotid artery segments, which compensates for arterial n...Keywords
This publication has 11 references indexed in Scilit:
- Carotid Plaque Developments: Aspects of Hemodynamic and Vessel Wall-Platelet InteractionCerebrovascular Diseases, 1991
- Variability of flow patterns in the normal carotid bifurcationAtherosclerosis, 1990
- Differential enlargement of artery segments in response to enlarging atherosclerotic plaquesJournal of Vascular Surgery, 1988
- Compensatory Enlargement of Human Atherosclerotic Coronary ArteriesNew England Journal of Medicine, 1987
- Outcome in Patients with Asymptomatic Neck BruitsNew England Journal of Medicine, 1986
- Age-related changes in carotid artery wall properties in menJapanese Journal of Clinical Oncology, 1986
- Duplex scanning in presumably normal persons of different agesJapanese Journal of Clinical Oncology, 1986
- SPONTANEOUS PROGRESSION AND REGRESSION OF SMALL CAROTID ATHEROMAThe Lancet, 1985
- Structural details of boundary layer separation in a model human carotid bifurcation under steady and pulsatile flow conditionsJournal of Vascular Surgery, 1985
- The size of human coronary arteries depending on the physiological and pathological growth of the heart the age, the size of the supplying areas and the degree of coronary sclerosisVirchows Archiv, 1982