Antibiotic Usage and Microbial Resistance in an Intensive Care Nursery
- 1 September 1973
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Pediatrics & Adolescent Medicine
- Vol. 126 (3), 318-321
- https://doi.org/10.1001/archpedi.1973.02110190280006
Abstract
Kanamycin sulfate was replaced by gentamicin sulfate in an effort to control an outbreak of nosocomial infections caused by enteric organisms with R-factor-mediated kanamycin resistance in an intensive care nursery. Within a month the kanamycin-resistant organisms were essentially eliminated from the nursery, indicating that the selective pressure provided by the extensive use of kanamycin was a major factor in causing and propagating the outbreak. Over a period of observation of 15 months, a significant increase in the gentamicin resistance of the Gram-negative intestinal flora of the infants occurred, but no clinical infections due to gentamicin-resistant enteric organisms were observed.Keywords
This publication has 3 references indexed in Scilit:
- The Current Status of Gentamicin for the Neonate and Young InfantArchives of Pediatrics & Adolescent Medicine, 1972
- Epidemiological Fingerprinting of Pseudomonas aeruginosa by the Production of and Sensitivity to Pyocin and Bacteriophage1Applied Microbiology, 1969
- Antimicrobial Therapy in the Neonatal PeriodPediatric Clinics of North America, 1961