Cyclohexadepsipeptides from the Insect Pathogenic Fungus Hirsutella nivea BCC 2594
- 1 November 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 68 (11), 1680-1682
- https://doi.org/10.1021/np050246n
Abstract
Two new cyclohexadepsipeptides, hirsutatins A (1) and B (2), were isolated from a culture filtrate of the insect pathogenic fungus Hirsutella nivea BCC 2594. Structures of these compounds were elucidated primarily by NMR and mass spectroscopic analyses. The α-carbon stereochemistry of 1 was established by HPLC analysis of its acid hydrolysate using a chiral column. Hirsutatin B (2) exhibited activity against the malarial parasite Plasmodium falciparum K1 with an IC50 value of 5.8 μg/mL, while hirsutatin A (1) was inactive at a concentration of 20 μg/mL.Keywords
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