Estrogen Receptors in Human Pituitary Adenomas*
- 1 October 1980
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 51 (4), 897-902
- https://doi.org/10.1210/jcem-51-4-897
Abstract
Estrogen-binding proteins were observed in the cytosol of human pituitary adenomas. The Kd for estradiol was 0.44 nM at 0.degree. C, and hormonal specificity was that expected for estrogen receptors. Sucrose gradient sedimentation experiments revealed that receptors from different tumors existed in either the 8S or the 4S form or both. Of the 23 tumors examined, 14 contained estrogen receptors. Receptors were more often present and their concentration was higher in prolactin-secreting adenomas (mean .+-. standard error of the mean, 20.7 .+-. 13.4 f[femto]mol/mg protein; 7 determinations) than in growth hormone-secreting adenomas (1.4 .+-. 0.8 fmol/mg protein; 9 determinations) and chromophobe tumors (4.1 .+-. 1.6 fmol/mg protein; 7 determinations). There was also a correlation between the presence of estrogen receptors and histological signs of cell proliferation and tumor growth.This publication has 4 references indexed in Scilit:
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